R0654

Reveromycin A

solid, suitable for cell culture, BioReagent

• Empirische Formel (Hill-System): C₃₆H₅₂O₁₁
• CAS-Nummer: 134615-37-5
• Molekulargewicht: 660.79
• UNSPSC Code: 12352207
• PubChem Substance ID: 24899342
• NACRES: NA.76
• MDL number: MFCD00912537

Eigenschaften

• Produktname: Reveromycin A, solid
• biological source: Streptomyces sp.
• Quality Segment: 200
• form: solid
• mol wt: 660.79 g/mol
• packaging: pkg of 100 μg
• color: tan
• solubility: DMF: soluble, DMSO: soluble, ethanol: soluble, ethyl acetate: soluble, methanol: soluble, soluble
• antibiotic activity spectrum: fungi
• mode of action: protein synthesis | interferes
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: [H][C@]1(C\C=C(C)\C=C\[C@H](O)[C@@H](C)\C=C\C(O)=O)O[C@]2(CC[C@@H]1C)CC[C@@](CCCC)(OC(=O)CCC(O)=O)[C@@]([H])(O2)\C=C\C(C)=C\C(O)=O
• InChI: 1S/C36H52O11/c1-6-7-19-35(47-34(44)17-16-32(40)41)21-22-36(46-30(35)14-10-25(3)23-33(42)43)20-18-27(5)29(45-36)13-9-24(2)8-12-28(37)26(4)11-15-31(38)39/h8-12,14-15,23,26-30,37H,6-7,13,16-22H2,1-5H3,(H,38,39)(H,40,41)(H,42,43)/b12-8+,14-10+,15-11+,24-9+,25-23+/t26-,27-,28-,29+,30-,35+,36-/m0/s1
• InChI key: ZESGNAJSBDILTB-OXVOKJAASA-N

Beschreibung

Biochem/physiol Actions

Reveromycin A is a polyketide antibiotic from Streptomyces sp. Epidermal growth factor (EGF) inhibitor; apoptosis inducer; G₁ phase cell cycle inhibitor having antiproliferative behavior against human cell lines KB and K562 as well as antifungal activity.

It is an epidermal growth factor (EGF) and eukaryotic cell growth inhibitor.

Analysis Note

Avoid acidic conditions.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)