P9389

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt

double stranded, alternating copolymer

• Synonym(e): Poly(dG-dC) • Poly(dG-dC)
• CAS-Nummer: 90385-88-9
• UNSPSC Code: 41106305
• NACRES: NA.51
• MDL number: MFCD00131968
• Biological source: synthetic (organic)
• Form: powder or solid
• Storage temp.: −20°C

Eigenschaften

• biological source: synthetic (organic)
• Quality Segment: 200
• form: powder or solid
• storage temp.: −20°C

Beschreibung

General description

Poly(deoxyguanylic-deoxycytidylic) acid (poly(dG-dC)) undergoes salt dependent conformational transition. Under high-salt, it exists as a left-handed double helix and at low-salt it displays B-DNA conformation. However on immobilization, poly(dG-dC) takes up A DNA form.

Application

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt has been used:

• in electrophoretic mobility shift assay of transcription factor IIIB complex
• as synthetic copolymers for circular dichroism (CD) spectroscopy studies[1]
• as a positive control in liquid scintillation counting

Poly(deoxyguanylic-deoxycytidylic) acid (Poly(dG-dC) • Poly(dG-dC)) is an alternating copolymer, self-complementary, double-stranded DNA model for conformational studies of DNA structure dynamics and drug interaction.

Other Notes

Alternating copolymer; self-complementary, form double-stranded complex

One unit will yield an A₂₆₀ of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)