This product is tested for solubility in methanol at 50 mg/mL and is also soluble in ethanol and DMSO. The stability in solution has not been determined. However, an identical product, 524488, notes that solutions are stable when stored in aliquots at -20°C for up to 1 month.
Fortfahren mit
P7912
Phloretin
≥99% (HPLC), powder, GLUT inhibitor
Synonym(e):
β-(4-Hydroxyphenyl)-2,4,6-trihydroxy-propiophenon, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanon
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 80,70 |
100 mg | Warenkorb auf Verfügbarkeit prüfen | € 179,00 |
250 mg | Warenkorb auf Verfügbarkeit prüfen | € 256,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C15H14O5
CAS-Nummer:
Molekulargewicht:
274.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
200-488-7
MDL number:
Beilstein/REAXYS Number:
1887240
Assay:
≥99%
Form:
powder
€ 80,70
Warenkorb auf Verfügbarkeit prüfen
Technischer Dienst
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Unterstützung erhaltenProduktname
Phloretin, ≥99%
Quality Segment
assay
≥99%
form
powder
mp
~260 °C
storage temp.
2-8°C
SMILES string
Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
InChI
1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
InChI key
VGEREEWJJVICBM-UHFFFAOYSA-N
General description
Major polyphenol found in apple; aglycone of phloridzin.
Phloretin a polar dye belongs to the class of dihydrochalcones.[1]
Application
Phloretin has been used:
- to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-l-glucose (2-NBDLG) uptake
- to incubate microvesicles in order to inhibit GLUT1 (glucose transporter 1)-mediated transport in radioactive ligand up-take assay
- as a component of KRH buffer to stop glucose uptake by trophoblast cells in vitro
Biochem/physiol Actions
Blocks L-type Ca2+ channels; activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers. Monocarboxylate transporter inhibitor.
Reacts with vic-dicarbonyl compounds such as glyoxal and methylglyoxal, preventing cytotoxic conjugation with biological macromolecules.
Phloretin is known to decrease interfacial dipole potential of lipid bilayer. Phloretin possess antitumor action by preventing protein kinase C (PKC) activity and stimulating programmed cell death. It is found to inhibit the transport functions of GLUTs (glucose transporter) and aquaporins.
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Dieser Artikel | |||
|---|---|---|---|
| form powder | form solid | form solid | form powder |
| assay ≥99% | assay ≥95.0% (HPLC) | assay ≥97% (TLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level - | Quality Level 100 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. - | storage temp. −20°C | storage temp. 2-8°C |
| mp ~260 °C | mp ~260 °C | mp - | mp - |
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Lagerklasse
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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この製品の溶解方法と溶解した後の保存方法と、保存可能期間をどうか教えてください。 Please let me know how to dissolve this product, how to store it, and how long it can be stored after dissolving.
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What is the solubility of Phloretin in DMSO?
1 answer-
Stock solutions of phloretin can be prepared in DMSO at 100 mM
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