P7888

DL-Propargylglycine

cystathionine γ-lyase inhibitor

• Synonym(e): 2-Amino-4-pentynoic acid, PAG
• Empirische Formel (Hill-System): C₅H₇NO₂
• CAS-Nummer: 64165-64-6
• Molekulargewicht: 113.11
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24898885
• NACRES: NA.26
• MDL number: MFCD00056728

Eigenschaften

• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• color: white
• application(s): cell analysis
• storage temp.: −20°C
• SMILES string: NC(CC#C)C(O)=O
• InChI: 1S/C5H7NO2/c1-2-3-4(6)5(7)8/h1,4H,3,6H2,(H,7,8)
• InChI key: DGYHPLMPMRKMPD-UHFFFAOYSA-N

Beschreibung

Application

• Metabolic Labeling Strategy Boosted Antibacterial Efficiency for Photothermal and Photodynamic Synergistic Bacteria-Infected Wound Therapy.: This study demonstrates the enhanced antibacterial efficiency of a metabolic labeling strategy using ᴅʟ-Propargylglycine in photothermal and photodynamic therapy for treating bacteria-infected wounds (Li et al., 2022).


• Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables In Vivo Imaging of Gut Microbiota.: This research utilizes ᴅʟ-Propargylglycine for metabolic labeling, allowing near-infrared II imaging of gut microbiota in vivo, providing new insights into microbiome studies (Wang et al., 2020).


• Hydrogen sulfide upregulated mRNA expressions of sodium bicarbonate cotransporter1, trefoil factor1 and trefoil factor2 in gastric mucosa in rats.: Investigates the role of ᴅʟ-Propargylglycine, in upregulating specific mRNA expressions in gastric mucosa, with implications for gastrointestinal research (Cheraghi et al., 2016).

Biochem/physiol Actions

DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H₂S).

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves