P6402

Perphenazin

• Synonym(e): 4-[3-(2-Chlor-10H-phenothiazin-10-yl)-propyl]-1-piperazinethanol
• Empirische Formel (Hill-System): C₂₁H₂₆ClN₃OS
• CAS-Nummer: 58-39-9
• Molekulargewicht: 403.97
• NACRES: NA.77
• PubChem Substance ID: 24278642
• UNSPSC Code: 12352200
• EC Number: 200-381-5
• MDL number: MFCD00056798
• Form: powder

Eigenschaften

• form: powder
• Quality Segment: 200
• originator: Schering Plough
• storage temp.: 2-8°C
• SMILES string: ClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
• InChI: 1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
• InChI key: RGCVKNLCSQQDEP-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), OPRS1(10280)

Beschreibung

General description

Perphenazine is an antipsychotic drug used in treating schizophrenia. It modulates antioxidant levels and helps in the management of oxidative injury in schizophrenia. However, it is less effective than the clozapine drug group in improving response to oxidative injury.

Biochem/physiol Actions

D₂ dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H317
• pcodes: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3