P5585

Palmitinsäure

BioXtra, ≥99%

• Synonym(e): 1-Pentadecancarbonsäure, C16:0, Cetylsäure, Hexadecansäure, NSC 5030, PamOH
• Lineare Formel: CH₃(CH₂)₁₄COOH
• CAS-Nummer: 57-10-3
• Molekulargewicht: 256.42
• Beilstein: 607489
• EG-Nummer: 200-312-9
• MDL-Nummer: MFCD00002747
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24898674
• NACRES: NA.25

Eigenschaften

• Biologische Quelle: plant (vegetable)
• Dampfdruck: 10 mmHg ( 210 °C)
• Produktlinie: BioXtra
• Assay: ≥99%
• Form: powder
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• Glührückstand: ≤0.1%
• bp: 271.5 °C/100 mmHg (lit.)
• mp (Schmelzpunkt): 61-62.5 °C (lit.)
• Löslichkeit: chloroform: 0.5 M, clear, colorless
• Dichte: 0.852 g/mL at 25 °C (lit.)
• Anionenspuren: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• Kationenspuren: Al: ≤0.005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.05%; Pb: ≤0.001%; Zn: ≤0.0005%
• Funktionelle Gruppe: carboxylic acid
• Lipid-Typ: saturated FAs
• Versandbedingung: ambient
• Lagertemp.: room temp
• SMILES String: CCCCCCCCCCCCCCCC(O)=O
• InChI: 1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
• InChIKey: IPCSVZSSVZVIGE-UHFFFAOYSA-N
• Angaben zum Gen: human ... FABP2(2169) , FABP3(2170) , FABP4(2167) , FABP5(2171)

Beschreibung

Anwendung

Palmitic acid has been used:

• as a medium supplement in chorionic villous tissue culture form placenta
• as a component of hormone pellet for implantation in mice ovary
• for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1

Biochem./physiol. Wirkung

Palmitic acid (PA) is a component of membrane phospholipids (PL) and adipose triacylglycerols (TAG). Elevated levels of palmitic acid contributes to the pathophysiology of atherosclerosis, type 2 diabetes mellitus, neurodegenerative diseases, obesity and cancer. PA promotes apoptosis in the endothelial cell by modulating the p38 mitogen-activated protein kinase (MAPK) pathway and favors expression of TNF-α and reactive oxygen species accumulation. PA promotes interleukin 8 (IL-8) synthesis in hepatocytes contributing to hepatic inflammation. PA by interacting with toll-like receptor 4 (TLR4) induces inflammatory injury in cardiomyoctes.

Palmitic acid is a straight-chain 16-carbon fatty acid. Diets rich in palmitic acid, along with lauric and myristic acids, are associated with increased serum levels of low-density lipoprotein cholesterol. Palmitic acid is the first fatty acid produced by lipogenesis. It is a negative regulator of acetyl-CoA carboxylase (ACC) and is implicated in fatty acid-induced insulin resistance.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: nwg
• Flammpunkt (°F): 235.4 °F
• Flammpunkt (°C): 113 °C
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves