P1306

Peptide YY human

≥97% (HPLC), synthetic

• Synonym(e): PYY, Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH₂
• Empirische Formel (Hill-System): C₁₉₄H₂₉₅N₅₅O₅₇
• CAS-Nummer: 118997-30-1
• Molekulargewicht: 4309.75
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD00081843

Eigenschaften

• biological source: synthetic
• assay: ≥97% (HPLC)
• form: solid
• UniProt accession no.: P10082
• storage temp.: −20°C
• Quality Level: 200
• Gene Information: human ... PYY(5697)

Beschreibung

General description

Human peptide YY (PYY) is secreted by mucosal L cells in the distal ileum, colon and rectum. It consists of 36 amino acids. The gene encoding PYY is localized on human chromosome 17q21.1.[1][2][3]

Application

Peptide YY human has been used as a supplement in Roswell Park Memorial Institute medium (RPMI medium) to culture pancreatic duct-derived cells.[3]

Biochem/physiol Actions

Gut hormone that inhibits both secretin and cholecystokinin-stimulated pancreatic secretion. Endogenous nonselective agonist at NPY receptors.

Human peptide YY (PYY) has a role in food ingestion, gut motility and insulin secretion. The protein suppresses appetite. It has been associated with obesity and type 2 diabetes. PYY also has a role in energy homeostasis.[4][2]

Inhibits secretin and cholecystokinin-stimulated pancreatic secretion;endogenous nonselective agonist at NPY receptors.

Other Notes

Lyophilized from 0.1% TFA in H2O

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)