P0099

Paliperidon

≥98% (HPLC), risperidone metabolite, powder

• Synonym(e): 3-[2-[4-(6-Fluor-1,2-benzisoxazol-3-yl)-1-piperidinyl]-ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on, 9-Hydroxy-risperidon
• Empirische Formel (Hill-System): C₂₃H₂₇FN₄O₃
• CAS-Nummer: 144598-75-4
• Molekulargewicht: 426.48
• UNSPSC Code: 12352200
• PubChem Substance ID: 329820012
• NACRES: NA.77
• MDL number: MFCD00871802
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Paliperidon, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to brown
• solubility: DMSO: 2 mg/mL, clear (warmed)
• originator: Johnson & Johnson
• storage temp.: room temp
• SMILES string: CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1
• InChI: 1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3
• InChI key: PMXMIIMHBWHSKN-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), HTR2A(3356)

Beschreibung

Application

Paliperidone has been used as an atypical antipsychotic drug (AAPD) to study its efficacy in preventing psychopathology of mice prenatally immune challenged with lipopolysaccharide (LPS).[1] It has also been used as an atypical antipsychotic drug (AAPD) to explain the modulation of hypothalamic-pituitary-adrenal (HPA) axis in female mice prenatally treated with bacterial endotoxin lipopolysaccharide (LPS).[2]

Biochem/physiol Actions

Paliperidone is an atypical antipsychotic; active metabolite of risperidone.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges