O4139

Orlistat

≥98% (HPLC), solid, lipase inhibitor

• Synonym(e): (−)-Tetrahydrolipstatin, N-Formyl-L-leucin-(1S)-1-{[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]-methyl}-dodecylester, Ro-18-0647
• Empirische Formel (Hill-System): C₂₉H₅₃NO₅
• CAS-Nummer: 96829-58-2
• Molekulargewicht: 495.73
• UNSPSC Code: 41106300
• PubChem Substance ID: 24724564
• NACRES: NA.77
• MDL number: MFCD05662360
• Assay: ≥98%
• Form: solid

Eigenschaften

• Produktname: Orlistat, ≥98%, solid
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98%
• form: solid
• color: white
• mp: <50 °C
• solubility: DMSO: 19 mg/mL
• originator: Roche
• storage temp.: 2-8°C
• SMILES string: CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
• InChI: 1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
• InChI key: AHLBNYSZXLDEJQ-FWEHEUNISA-N
• Gene Information: human ... LIPF(8513), PNLIP(5406)

Beschreibung

General description

Orlistat acts as a gastric lipase inhibitor that reduces fat absorption.[1]

Application

Orlistat has been used as an inhibitor:

• of fatty acid synthase in long-term estrogen-deprived (LTED) variant cell lines
• of lipase in screening lipase inhibition by raspberry extract
• in in vitro pancreatic lipase activity assay

Biochem/physiol Actions

Orlistat impairs intestinal fat absorption and is effective in weight management. It is regarded as a safe drug for treating obesity. It delays the progression of type 2 diabetes mellitus especially in obese and improves glycemic parameters.[2] Long term usage of orlistat results in improved weight reduction and it may not contribute in colorectal carcinogenesis.

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Solution is not completely clear, small particles may remain floating.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)