O3139

Oxamflatin

≥98% (HPLC), solid

• Synonym(e): (2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid
• Empirische Formel (Hill-System): C₁₇H₁₄N₂O₄S
• CAS-Nummer: 151720-43-3
• Molekulargewicht: 342.37
• NACRES: NA.77
• PubChem Substance ID: 329818905
• UNSPSC Code: 12352203
• MDL number: MFCD00949087
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: soluble 13 mg/mL
• storage temp.: 2-8°C
• SMILES string: ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1
• InChI: 1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+
• InChI key: QRPSQQUYPMFERG-LFYBBSHMSA-N

Beschreibung

Application

Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor:

• to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells
• to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation
• to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system
• to study its stand-alone effect on cytarabine-sensitive and resistant cells.

Biochem/physiol Actions

Histone deacetylase inhibitor; anti-cancer agent.

Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)