O0641

Oroxylin A

≥98% (HPLC)

• Synonym(e): 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-on, 5,7-Dihydroxy-6-methoxyflavone, 6-Methoxybaicalein
• Empirische Formel (Hill-System): C₁₆H₁₂O₅
• CAS-Nummer: 480-11-5
• Molekulargewicht: 284.26
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818889
• MDL number: MFCD02259441

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1c(O)cc2OC(=CC(=O)c2c1O)c3ccccc3
• InChI: 1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3
• InChI key: LKOJGSWUMISDOF-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean/Chinese/Japanese medicine. It shows amelioration of Abeta(25-35) peptide-induced memory impairment.

Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean/Chinese/Japanese medicine. The amelioration of Abeta(25-35) peptide-induced memory impairment by oroxylin A is believed to be mediated via the GABAergic neurotransmitter system after a single administration, or by reductions in Abeta(25-35) peptide-induced astrocyte and microglia activations, iNOS expression, lipid peroxidation, and increased cholinergic neurotransmission after subchronic administration.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 + P330 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable