N4788

Anti-NOTCH1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-TAN1, Anti-Notch homolog 1 (Drosophila)
• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: 8

Eigenschaften

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): immunohistochemistry: 1:100-1:200, western blot: 1:500-1:1,000
• UniProt accession no.: P46531
• application(s): research pathology
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NOTCH1(4851) ; mouse ... Notch1(18128) ; rat ... Notch1(25496)

Beschreibung

General description

NOTCH homolog-1 (NOTCH-1) is a transmembrane receptor.

Immunogen

synthetic peptide corresponding to residues 2170-2187 of human NOTCH1.

Biochem/physiol Actions

NOTCH homolog-1 (NOTCH-1) is an integral part of the NOTCH signaling pathway, which regulates various cellular functions. NOTCH-1 enhances the invasion of cancer cells and mutations in the gene encoding it have been associated with chronic lymphocytic leukemia (CLL).

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)