Nomifensine maleate salt

Name: Nomifensine maleate salt
Brand: SIGMA

dopamine uptake inhibitor , powder

Synonym(e):

1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate salt

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₆H₁₈N₂ · C₄H₄O₄

CAS-Nummer:

32795-47-4

Molekulargewicht:

354.40

NACRES:

NA.77

PubChem Substance ID:

24277920

UNSPSC Code:

12352200

EC Number:

251-223-7

MDL number:

MFCD00069320

Form:

powder

Technischer Dienst

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Eigenschaften

Produktname

Nomifensine maleate salt,

form

powder

Quality Segment

200

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CN1CC(c2ccccc2)c3cccc(N)c3C1

InChI

1S/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

GEOCVSMCLVIOEV-BTJKTKAUSA-N

Gene Information

human ... DBH(1621), SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)

Beschreibung

Application

Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.

Biochem/physiol Actions

Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter, at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.