N1413

NSCI

≥97% (HPLC), solid

• Synonym(e): 1-(4-Methyoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
• Empirische Formel (Hill-System): C₂₆H₂₅N₃O₆S
• CAS-Nummer: 872254-32-5
• Molekulargewicht: 507.56
• UNSPSC Code: 12352200
• PubChem Substance ID: 24897488
• NACRES: NA.77
• Assay: ≥97% (HPLC)
• Form: solid

Eigenschaften

• assay: ≥97% (HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N4CCC[C@H]4COc5cccnc5)cc1
• InChI: 1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-17H2,1H3/t19-/m0/s1
• InChI key: XDHJBIYJRNFDKS-IBGZPJMESA-N
• Gene Information: human ... CASP1(834), CASP3(836), CASP6(839), CASP7(840), SUMO1(7341)

Beschreibung

Application

NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells. It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4⁺) and cluster of differentiation 8 (CD8⁺) T cells from pleural effusions, mononuclear cells (PEMCs).

Biochem/physiol Actions

1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable