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N0267

(±)-Nikotin

Name: (±)-Nikotin
Brand: SIGMA

≥99% (TLC), nicotinic acetylcholine receptor agonist, liquid

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₀H₁₄N₂

CAS-Nummer:

22083-74-5

Molekulargewicht:

162.23

UNSPSC Code:

12352210

eCl@ss:

39151701

PubChem Substance ID:

24897418

NACRES:

NA.77

Beilstein/REAXYS Number:

82108

MDL number:

MFCD00065370

Assay:

≥99% (TLC)

Form:

liquid

Technischer Dienst

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Eigenschaften

Produktname

(±)-Nikotin, ≥99% (TLC), liquid

Quality Segment

200

assay

≥99% (TLC)

form

liquid

optical activity

[α]25/D 0°(lit.)

color

yellow

solubility

ethanol: 50 mg/mL

density

1.02 g/mL at 25 °C (lit.)

SMILES string

CN1CCCC1c2cccnc2

InChI

1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3

InChI key

SNICXCGAKADSCV-UHFFFAOYSA-N

Gene Information

human ... CHRNA2(1135), CHRNA3(1136), CHRNA4(1137)
rat ... Chrna3(25101), Chrna4(25590), Chrna7(25302)

Beschreibung

Application

(±)-Nicotine has been used:

as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
as a test compound to study its effects on fibril formation

Biochem/physiol Actions

Prototype nicotinic acetylcholine receptor agonist.

(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.

Packaging

The material is liquid, transparent, and viscous, packaged in amber vail, and the volume inserted into each bottle is very small, It may form a thin FILM on the sides. While it may be difficult to see the material inside by the eyes, the container is not empty.