M9948

Mirin

≥98% (HPLC), Mre11–Rad50–Nbs1 complex inhibitor, powder

• Synonym(e): 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one
• Empirische Formel (Hill-System): C₁₀H₈N₂O₂S
• CAS-Nummer: 299953-00-7
• Molekulargewicht: 220.25
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818100
• NACRES: NA.77
• MDL number: MFCD05885480
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: Mirin, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: red to orange
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2
• InChI: 1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-
• InChI key: YBHQCJILTOVLHD-YVMONPNESA-N
• Gene Information: human ... MRE11A(4361)

Beschreibung

Application

Mirin has been used:

• as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
• as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
• in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)

Biochem/physiol Actions

Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.

Mirin is an inhibitor of the Mre11–Rad50–Nbs1 complex.

Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable