M7398

Monoclonal Anti-β₂-Microglobulin antibody produced in mouse

clone BM-63, ascites fluid

• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD00162400
• Conjugate: unconjugated
• Clone: BM-63, monoclonal
• Application: ELISA (i), IF
• Citations: 11

Eigenschaften

• biological source: mouse
• conjugate: unconjugated
• antibody form: ascites fluid
• antibody product type: primary antibodies
• clone: BM-63, monoclonal
• mol wt: antigen 12 kDa
• contains: 15 mM sodium azide
• species reactivity: human
• technique(s): indirect ELISA: 1:1000, indirect immunofluorescence: 1:500 using human PBL′s
• isotype: IgG1
• UniProt accession no.: P61769
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... B2M(567)

Beschreibung

General description

β-2-microglobulin is part of the human leukocyte antigen, where it represents the light chain. It is expressed on cell membranes and is made up of 99 amino acids. β-2-microglobulin is part of the immunoglobulin superfamily. β−2-Microglobulin is a membrane glycoprotein of mammalian nucleated cells including lymphocytes.

Monoclonal anti-β-2-Microglobulin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Immunogen

human β₂-microglobulin and a lysate of a lymphoblastoid cell line.

Application

Monoclonal Anti-β2-Microglobulin antibody produced in mouse has been used in ELISA and immunofluorescent labelling.

Biochem/physiol Actions

β-2-microglobulin acts as a tumor marker and has been shown to be associated with dialysis-related amyloidosis. It may function as a structural part of the MHC Class I molecule.

Microglobulin may be elevated in the serum or urine of patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, metal toxications, some viral infections and possibly malignant disorders and AIDS.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable