M2449

MB-3

≥95% (HPLC), Gcn5 HAT inhibitor, powder

• Synonym(e): γ-butyrolactone, Butyrolactone 3, (2R,3S)-rel-4-Methylene-5-oxo-2-propyltetrahydrofuran-3-carboxylic acid
• Empirische Formel (Hill-System): C₉H₁₂O₄
• Molekulargewicht: 184.19
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817942
• NACRES: NA.77
• MDL number: MFCD08702690
• Assay: ≥95% (HPLC)
• Form: powder

Eigenschaften

• Produktname: MB-3, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to off-white
• solubility: H₂O: ≥10 mg/mL, DMSO: ≥20 mg/mL
• storage temp.: −20°C
• SMILES string: CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
• InChI: 1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1
• InChI key: SRQUTZJZABSZRQ-RQJHMYQMSA-N

Beschreibung

Application

MB-3 has been used as a general control non-repressible 5 (GCN5) inhibitor:

• to study its effects on lamin A/C-associated pY19-Cav-2-mediated histone H3 acetylations[1]
• to analyze its effects on the growth of Arabidopsis thaliana seedlings[2]
• to study its effects on craniofacial chondrocyte maturation[3]

Biochem/physiol Actions

MB-3 can modify the gene expression in murine embryonic stem cells as well as yeast.[4] It hinders the acetyltransferase activity of general control non-repressible 5 (GCN5) by binding to acetyl CoA pocket present in GCN5.[3]

MB-3 is a Gcn5 HAT (Histone Acetyltransferase) inhibitor; anti-inflammatory, anti-carcinogenic.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable