Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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M0639
6α-Methylprednisolon
synthetic, ≥98%, glucocorticoid, powder
Synonym(e):
11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadien-3,20-dion, 6α-Methyl-11β,17a,21-trihydroxy-1,4-pregnadien-3,20-dion, Medrol, Medron
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| Ihnen/SKU | Verfügbarkeit | Preis |
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Über diesen Artikel
Empirische Formel (Hill-System):
C22H30O5
CAS-Nummer:
Molekulargewicht:
374.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
201-476-4
MDL number:
Beilstein/REAXYS Number:
2340300
Assay:
≥98%
Form:
powder
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Technischer Dienst
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Unterstützung erhaltenProduktname
6α-Methylprednisolon, ≥98%
biological source
synthetic
Quality Segment
sterility
non-sterile
assay
≥98%
form
powder
solubility
chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
application(s)
cell analysis
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
InChI
1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
InChI key
VHRSUDSXCMQTMA-PJHHCJLFSA-N
Gene Information
human ... NR3C1(2908)
rat ... Nr3c1(24413)
Application
6α-Methylprednisolone has been used:
- to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
- to induce depletion of CD14+ CD16+ monocytes
- to study its effect on behavioral and sensory afferent hypersensitivity
Biochem/physiol Actions
Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions. It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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Dieser Artikel | |||
|---|---|---|---|
| form powder | form - | form - | form powder |
| assay ≥98% | assay - | assay - | assay ≥97% |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level 100 |
| storage temp. room temp | storage temp. 2-30°C | storage temp. −20°C | storage temp. room temp |
| solubility chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow | solubility - | solubility - | solubility chloroform: methanol (1:1): 50 mg/mL, clear, colorless |
| shipped in ambient | shipped in - | shipped in - | shipped in ambient |
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signalword
Danger
hcodes
Hazard Classifications
Repr. 1B - STOT RE 2
target_organs
Adrenal gland,Immune system
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
ppe
Eyeshields, Gloves, type N95 (US)
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What is the Department of Transportation shipping information for this product?
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What solvents can be used for Methylprednisolone?
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Sigma tests the solublity of Methylprednisolone at 50 mg/ml in chloroform:methanol (1:1) yielding a clear, colorless to faint yellow solution. This product is practically insoluble in water, soluble 1 in 100 of dehydrated ethanol (10 mg/ml), slightly soluble in chloroform and ether; sparingly soluble in dioxan and methanol. It has been reported that this product is soluble in DMSO at a concentration of 100 mM. An NMR has been run using DMSO-d6 suggesting this product is soluble at 5-10 mg/ml in DMSO.
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