M0443

Mirtazapin

Name: Mirtazapin
Brand: SIGMA
Price: 186 EUR

≥98% (HPLC), 5-HT2 antagonist; 5-HT3, H1 and α2 antagonist, powder

Synonym(e):

(±)-1,2,3,4,10,14b-Hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepin

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10 MG

€ 186,00

50 MG

€ 624,00

€ 186,00

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₇H₁₉N₃

CAS-Nummer:

85650-52-8

Molekulargewicht:

265.35

UNSPSC Code:

12352200

PubChem Substance ID:

24724531

NACRES:

NA.77

MDL number:

MFCD00865427

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Produktname

Mirtazapin, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: 8 mg/mL, clear

SMILES string

CN1CCN2C(C1)c3ccccc3Cc4cccnc24

InChI

1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

InChI key

RONZAEMNMFQXRA-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HTR1A(3350), HTR2A(3356), HTR2C(3358), HTR7(3363)
mouse ... Slc6a2(20538)
rat ... Adra1a(29412), Drd1a(24316), Drd2(24318), Htr1a(24473), Htr2a(29595), Htr2c(25187), Slc6a3(24898), Slc6a4(25553)

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Dieser Artikel	BP842	PHR8952	1444279
Sigma-Aldrich M0443 Mirtazapine	BP842 Mirtazapine	Supelco PHR8952 Mirtazapine	USP 1444279 Mirtazapine
assay ≥98% (HPLC)	assay -	assay -	assay -
form powder	form solid	form -	form -
Quality Level 100	Quality Level -	Quality Level -	Quality Level -
solubility DMSO: 8 mg/mL, clear	solubility -	solubility -	solubility -
color white	color -	color -	color -
Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HTR1A(3350), HTR2A(3356), HTR2C(3358), HTR7(3363) mouse ... Slc6a2(20538) rat ... Adra1a(29412), Drd1a(24316), Drd2(24318), Htr1a(24473), Htr2a(29595), Htr2c(25187), Slc6a3(24898), Slc6a4(25553)	Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), HTR2A(3356), HTR2C(3358)	Gene Information -	Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), HTR2A(3356), HTR2C(3358)

Biochem/physiol Actions

Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). Mirtazapine agonizes selective adrenergic and serotonergic receptors so that both NE release and 5-HT_1A mediated serotonergic signaling are increased.

ppe

Eyeshields, Gloves, type N95 (US)

pictograms

GHS07

signalword

Warning

hcodes

H302,H336

pcodes

P261 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

0000524820

0000456489

0000427574

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

A review of the pharmacological and clinical profile of mirtazapine.

S A Anttila et al.

CNS drug reviews, 7(3), 249-264 (2001-10-19)

The novel antidepressant mirtazapine has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors. It enhances, therefore

Mirtazapine for treatment of depression and comorbidities in Alzheimer disease.

M A Raji et al.

The Annals of pharmacotherapy, 35(9), 1024-1027 (2001-09-28)

Depression in patients with Alzheimer disease is a treatable cause of functional decline, caregiver burden, and mortality. It is often associated with severe weight loss, insomnia, and anxiety. These symptoms independently and collaboratively further worsen the prognosis of these vulnerable

Low doses of alpha 2-adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance.

B Milne et al.

British journal of pharmacology, 155(8), 1264-1278 (2008-09-23)

Ultra-low doses of opioid receptor antagonists augment spinal morphine antinociception and block the induction of tolerance. Considering the evidence demonstrating functional and physical interactions between the opioid and alpha(2)-adrenoceptors, this study investigated whether ultra-low doses of alpha(2)-adrenoceptor antagonists also influence

Managing the side effects associated with commonly used treatments for bipolar depression.

David E Kemp

Journal of affective disorders, 169 Suppl 1, S34-S44 (2014-12-24)

The most commonly used pharmacologic therapies for bipolar depression are mood stabilizers, atypical antipsychotics, and antidepressants. This paper reviews common side effects associated with these medications and provides recommendations for managing adverse medication effects in clinical practice. Narrative review based

Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.

Carolina Muguruza et al.

Neuropharmacology, 86, 311-318 (2014-08-26)

Several studies have demonstrated alterations in serotonin 5-HT2A (5-HT2AR) and glutamate metabotropic mGlu2 (mGlu2R) receptors in depression, but never in the same sample population. Recently it has been shown that both receptors form a functional receptor heterocomplex that is altered

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Global Trade Item Number

SKU	GTIN
M0443-50MG	04061832082806
M0443-10MG	04061833993170

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Mirtazapin

≥98% (HPLC), 5-HT2 antagonist; 5-HT3, H1 and α2 antagonist, powder

Größe auswählen

M0443-10MG

€ 186,00

Über diesen Artikel

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Eigenschaften

Produktname

Quality Level

assay

form

color

solubility

SMILES string

InChI

InChI key

Gene Information

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Dieser Artikel

Beschreibung

Biochem/physiol Actions

Sicherheitshinweise

ppe

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

Lagerklasse

wgk

flash_point_f

flash_point_c

Dokumentation

Analysenzertifikate (COA)

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