L9919

LY2033298

≥98% (HPLC)

• Synonym(e): 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methyl-thieno[2,3-b]pyridine-2-carboxamide
• Empirische Formel (Hill-System): C₁₃H₁₄ClN₃O₂S
• CAS-Nummer: 886047-13-8
• Molekulargewicht: 311.79
• NACRES: NA.77
• PubChem Substance ID: 329817677
• UNSPSC Code: 12352200
• MDL number: MFCD12912423
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Eigenschaften

• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: off-white to tan
• solubility: DMSO: >20 mg/mL
• originator: Eli Lilly
• storage temp.: −20°C
• SMILES string: COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
• InChI: 1S/C13H14ClN3O2S/c1-5-7-9(15)10(11(18)16-6-3-4-6)20-13(7)17-12(19-2)8(5)14/h6H,3-4,15H2,1-2H3,(H,16,18)
• InChI key: CTEGQKDJTBWFHW-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

LY2033298 is a positive allosteric modulator of muscarinic M4 receptor.

LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 potentiates ACh-M4 binding, with no effect at M1/3/5 receptors. LY2033298 can also bind to the M ACh receptor, and mediate either positive or negative allosteric effects depending on the ligand used to probe receptor activity.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Danger
• hcodes: H334
• pcodes: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable