L4920

Luotonin E

≥98%

• Lineare Formel: C₁₉H₁₃N₃O₂
• CAS-Nummer: 244616-84-0
• Molekulargewicht: 315.33
• NACRES: NA.77
• UNSPSC Code: 12352202

Eigenschaften

• biological source: synthetic (organic)
• assay: ≥98%
• form: solid
• solubility: chloroform/methanol (4:1): 4 mg/mL, clear to slightly hazy, colorless to yellow
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... TOP1(7150)

Beschreibung

General description

Luotonin E is a heteroaromatic pyrroloquinazolinoquinoline alkaloid that, along with Luotonin A and B, was originally isolated from the Chinese medicinal plant Paganum nigellastrum. Luotonin compounds have antitumor activity and demonstrate cytotoxicity and inhibitory activity against human topoisomerase. For use as a topoisomerase inhibitor, a starting concentration of 25 μM is suggested. It is suggested that a dose-response curve be performed to find the inhibitor concentration most suitable for the intended assay.

Biochem/physiol Actions

Luotonin E exhibited strong cytotoxic effects specifically on human leukemia P-388 cells.

Preparation Note

Solubility is tested at 4 mg/mL in 4:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable