I9905

Interleukin-2/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, solution

• Synonym(e): IL-2:Fc (non-lytic)
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD03457247
• Biological source: mouse
• Recombinant: expressed in CHO cells
• Assay: >98% (SDS-PAGE)
• Form: solution
• Mol wt: 94 kDa
• Impurities: endotoxin, tested

Eigenschaften

• biological source: mouse
• Quality Segment: 200
• recombinant: expressed in CHO cells
• assay: >98% (SDS-PAGE)
• form: solution
• mol wt: 94 kDa
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• concentration: 0.1 mg/mL
• impurities: endotoxin, tested
• UniProt accession no.: P04351
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... Il2(16183)

Beschreibung

Biochem/physiol Actions

IL-2 (interleukin-2) is a cytokine which is involved in the differentiation of T cell and natural killer (NK) cell, T cell memory, activation-induced lymphocyte cell death. The protein also has a role in regulatory T cell (Treg) development and homeostasis. It is linked with the risk of Grave′s disease, rheumatoid arthritis, celiac disease, multiple sclerosis, psoriasis, Crohn′s disease, ulcerative colitis and type-1 diabetes (T1D).[1]

Possesses the biological functions of the IL-2 moiety and a prolonged circulating half-life determined by the Fc domain.

Physical form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Analysis Note

The biological activity is measured in a cell proliferation assay using CTLL2 cells.

Other Notes

Dimeric fusion protein consisting of mouse IL-2 fused to mutant mouse IgG2a Fc.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids