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I7256

Indol-3-Carbinol

Synonym(e):

3-Indolemethanol

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Über diesen Artikel

Empirische Formel (Hill-System):
C9H9NO
CAS-Nummer:
700-06-1
Molekulargewicht:
147.17
NACRES:
NA.25
PubChem Substance ID:
24896113
UNSPSC Code:
12352005
EC Number:
211-836-2
MDL number:
MFCD00005632
Quality level:
100

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Quality Level

100

mp

96-99 °C (lit.)

storage temp.

2-8°C

SMILES string

OCc1c[nH]c2ccccc12

InChI

1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2

InChI key

IVYPNXXAYMYVSP-UHFFFAOYSA-N

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Dieser Artikel
SMB00149SMB0054717793
Indole-3-carbinol

Sigma-Aldrich

I7256

Indole-3-carbinol

Quercetin 3-glucuronide ≥95% (LC/MS-ELSD)

Sigma-Aldrich

SMB00149

Quercetin 3-glucuronide

Quercetin 3,4′-diglucoside ≥85% (LC/MS-UV)

Sigma-Aldrich

SMB00547

Quercetin 3,4′-diglucoside

Quercetin 3-β-D-glucoside ≥90% (HPLC)

Sigma-Aldrich

17793

Quercetin 3-β-D-glucoside

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

mp

96-99 °C (lit.)

mp

-

mp

-

mp

-

General description

Indole-3-carbinol is a novel secondary plant metabolite produced in cruciferous vegetables, such as cabbage, cauliflower and brussels sprouts.

Application

Indole-3-carbinol has been used for encapsulation with poly-lactic-co-glycolic acid (PLGA), to study its in-vitro anti-cancerogenic effects on breast adenocarcinoma epithelial (MCF7), colon adenocarcinoma epithelial (Caco2), prostate carcinoma epithelial (PC3) cells. It has also been used as a cytochrome P4501A (CYP1A) inducer.

Biochem/physiol Actions

Indole-3-carbinol (I3C) activates aryl hydrocarbon receptor (AhR) and induces G1 cell cycle arrest and apoptosis. Thus, it acts as a potential anti-cancer agent. In addition, it induces estradiol metabolism by stimulating cytochrome P450 enzymes. Therefore, I3C is considered to be a potent chemotherapeutic for various types of cancer including, breast, prostate, colon cancer, and leukemia.
Inhibits cancinogenesis at the initiation stage. Has be shown to inhibit carcinogenesis in several animal species, but it enhances tumor incidence if administered at a post-initiation stage. Found in cruciferous vegetables.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Lagerklasse

11 - Combustible Solids

ppe

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKCV9482
MKCS2421
MKCJ9582
MKBZ5038V
MKBS5981V

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Die Dokumentenbibliothek aufrufen

Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line
Mohammadi S, et al.
Journal of Receptor and Signal Transduction Research, 37(5), 506-514 (2017)
Catherine J Leader et al.
PloS one, 14(8), e0220837-e0220837 (2019-08-14)
Is global longitudinal strain (GLS) a more accurate non-invasive measure of histological myocardial fibrosis than left ventricular ejection fraction (LVEF) in a hypertensive rodent model. Hypertension results in left ventricular hypertrophy and cardiac dysfunction. Speckle-tracking echocardiography has emerged as a
Youngshim Choi et al.
The Journal of nutritional biochemistry, 23(12), 1732-1739 (2012-05-10)
Indole-3-carbinol (I3C) is a compound found in high concentrations in Brassica family vegetables, including broccoli, cauliflower and cabbage, and is regarded as a promising chemopreventive agent against various cancers. This study assesses the protective effect of I3C against diet-induced obesity
Stephen Safe et al.
Cancer letters, 269(2), 326-338 (2008-05-27)
Indole-3-carbinol (I3C) conjugates are phytochemicals expressed in brassica vegetables and have been associated with the anticancer activities of vegetable consumption. I3C and its metabolite bis(3'-indolyl)methane (DIM) induce overlapping and unique responses in multiple cancer cell lines and tumors, and these
Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice
Bradlow HL, et al.
Carcinogenesis, 12(9), 1571-1574 (1991)
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Global Trade Item Number

SKUGTIN
I7256-1G04061833858097
I7256-25G04061833858103
I7256-5G04061833858110

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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