I5532

Anti-Interleukin-21 Receptor, N-Terminal antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-IL-21R
• UNSPSC Code: 51111800
• MDL number: MFCD03455325

Eigenschaften

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~60 kDa
• species reactivity: human
• concentration: ~0.5 mg/mL
• technique(s): western blot: 0.5-1 μg/mL
• UniProt accession no.: Q9HBE5
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... IL21R(50615)

Beschreibung

Immunogen

synthetic peptide corresponding to amino acids 20-32 of human IL-21 receptor precursor.

Biochem/physiol Actions

Interleukin-21 (IL-21) is a cytokine that regulates both innate and adaptive immunity. The biological effects of IL-21 are mediated by a heterodimeric receptor made up of IL-21R and a γ chain subunit. IL-21R is expressed in liver, thymus, dendritic cells , lymph nodes and spleen. Binding of IL-21 to the receptor leads to activation of JAK (JAK1 and JAK3), STAT (STAT1, 3, 4 and 5) proteins. IL-21R is important for sustained T cell responses during chronic viral infections, production of interferons against pathogens and protection against tumor formation.

Features and Benefits

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Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.