H9414

Halofantrin -hydrochlorid

≥98% (HPLC), HERG channel blocker, solid

• Synonym(e): 1,3-Dichlor-α-[2-(dibutylamino)-ethyl]-6-(trifluormethyl)-9-phenanthrenmethanol -hydrochlorid, Halfan
• Empirische Formel (Hill-System): C₂₆H₃₀Cl₂F₃NO · HCl
• CAS-Nummer: 36167-63-2
• Molekulargewicht: 536.88
• NACRES: NA.77
• PubChem Substance ID: 329815264
• UNSPSC Code: 12352200
• EC Number: 252-895-4
• MDL number: MFCD00879136
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Eigenschaften

• Produktname: Halofantrin -hydrochlorid, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: Cl.CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F
• InChI: 1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H
• InChI key: WANGFTDWOFGECH-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Halofantrin ist ein Blocker des verzögerten Gleichrichter-Kaliumstroms via die Hemmung des hERG Kanals.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Gefahrencodes: H413
• Sicherheitshinweise: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)