Product H7779, Retinoic acid p-hydroxyanilide, can be dissolved in DMSO (25 mg/ml) and ethanol (25 mg/ml).
H7779
Retinoic acid p-hydroxyanilide
≥95%
Synonym(e):
4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Über diesen Artikel
Empirische Formel (Hill-System):
C26H33NO2
CAS-Nummer:
Molekulargewicht:
391.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Fortfahren mit
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenInChI
1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
SMILES string
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1
InChI key
AKJHMTWEGVYYSE-FXILSDISSA-N
biological source
synthetic (organic)
assay
≥95%
form
powder
color
yellow to yellow-orange
storage temp.
−20°C
Quality Level
Verwandte Kategorien
1 of 4
Dieser Artikel | |||
|---|---|---|---|
| form powder | form powder | form (Powder or Crystal with Lumps) | form (Powder or Powder with Lumps) |
| assay ≥95% | assay ≥98% (HPLC) | assay ≥95.0% (HPLC) | assay ≥97.5% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| color yellow to yellow-orange | color yellow | color yellow to dark yellow | color faint yellow to very dark yellow |
| biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic | biological source synthetic |
General description
Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.
Application
Biochem/physiol Actions
Retinoic acid p-hydroxyanilide, also called fenretinide, increases reactive oxygen species, activates caspases and induces apoptosis. It also inhibits dihydroceramide desaturase, leading to a decrease in ceramide biosynthesis.[1] Fenretinide may elicit anticancer activity in cultured human breast cancer cells.[1] It acts as an insulin antagonist and may be useful in treating insulin resistance.[1] Fenretinide or 4-HPR has chemotherapeutic potential and is cytotoxic to retinoic acid-resistant cancers.[2]
Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Claude Lachance et al.
Infection and immunity, 82(5), 1778-1785 (2014-02-20)
Streptococcus suis is an important swine pathogen and an emergent zoonotic pathogen. Excessive inflammation caused by S. suis is responsible for early high mortality in septic shock-like syndrome cases. Polyunsaturated fatty acids (PUFAs) may contribute to regulating inflammatory processes. This
Chunxiao Wang et al.
Biochemical and biophysical research communications, 493(4), 1555-1559 (2017-10-11)
In the absence of approved therapeutics, Zika virus (ZIKV)'s recent prolific outbreaks in the Americas, together with impacts on unborn fetuses of infected mothers, make it a pressing human health concern worldwide. Although a key player in viral replication in
Hui Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(14), 5606-5611 (2013-03-21)
Leukemia stem cells (LSCs) play important roles in leukemia initiation, progression, and relapse, and thus represent a critical target for therapeutic intervention. However, relatively few agents have been shown to target LSCs, slowing progress in the treatment of acute myelogenous
Matthew J Watt et al.
Endocrine reviews, 40(5), 1367-1393 (2019-05-18)
The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most common chronic
C Marth et al.
Journal of the National Cancer Institute, 75(5), 871-875 (1985-11-01)
The synthetic retinoid 4-hydroxyphenylretinamide (HPR) showed antiproliferative effect on cultured human breast cancer cells, which were sensitive to retinoic acid (RA) too. Investigation of the cell cycle by flow cytophotometry showed a significant increase of cells in the S-phase of
-
In what solvents can product H7779, Retinoic acid p-hydroxyanilide, be dissolved?
1 answer-
Helpful?
-
-
What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
-
-
How can one store a solution of product H7779, Retinoic acid p-hydroxyanilide?
1 answer-
A solution of product H7779, Retinoic acid p-hydroxyanilide, can be aliquoted and stored at -20°C for up to 3 months. Solutions should be protect from light.
Helpful?
-
Active Filters
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
Setzen Sie sich mit dem technischen Dienst in Verbindung