Direkt zum Inhalt
Merck
Alle Fotos(1)

Dokumente

H6904

Sigma-Aldrich

6β-Hydroxycortisol

≥98%

Synonym(e):

4-Pregnene-6,11β,17,21-tetrol-3,20-dione

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C21H30O6
CAS-Nummer:
3078-34-0
Molekulargewicht:
378.46
MDL-Nummer:
MFCD00200405
UNSPSC-Code:
51111800
PubChem Substanz-ID:
24895777
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Sterilität

non-sterile

Assay

≥98%

Form

powder

Methode(n)

HPLC: suitable

Löslichkeit

methanol: 50 mg/mL, clear, colorless

Versandbedingung

ambient

Lagertemp.

room temp

SMILES String

CC12CCC(=O)C=C1C(O)CC3C4CC[C@](O)(C(=O)CO)C4(C)CC(O)C23

InChI

1S/C21H30O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t12?,13?,15?,16?,18?,19?,20?,21-/m0/s1

InChIKey

GNFTWPCIRXSCQF-JFQOUMBGSA-N

Anwendung

6β-Hydroxycortisol has been used in liquid chromatography with tandem mass spectrometry (LC/MS/MS) analysis to confirm the human embryonic kidney (HEK293) cell-based conversion of parent cortisol to 6β-hydroxycortisol (6βOH) metabolites.

Biochem./physiol. Wirkung

6β-Hydroxycortisol serves as a substrate for the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins (MATE1 and MATE-2K).
6β-Hydroxycortisol is a metabolite of cortisol.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Yuichiro Imamura et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(4), 685-694 (2014-02-04)
6β-Hydroxycortisol (6β-OHF) is a substrate of the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-transfected cells. This study aimed to examine the contribution of OAT3 and MATEs to the
Kevin A Lidberg et al.
Scientific reports, 11(1), 4722-4722 (2021-02-27)
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and hypertension, however, most investigators have
Kevin A Lidberg et al.
Scientific reports, 11(1), 4722-4722 (2021-02-27)
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and hypertension, however, most investigators have

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.