F4381

Furosemid

≥98% (HPLC), powder, NKCC symporter inhibitor

• Synonym(e): 4-Chlor-N-furfuryl-5-sulfamoylanthranilsäure, 5-(Aminosulfonyl)-4-chlor-2-[(2-furanylmethyl)-amino]-benzoesäure
• Empirische Formel (Hill-System): C₁₂H₁₁ClN₂O₅S
• CAS-Nummer: 54-31-9
• Molekulargewicht: 330.74
• NACRES: NA.77
• PubChem Substance ID: 24277714
• UNSPSC Code: 12352200
• EC Number: 200-203-6
• MDL number: MFCD00010549
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Furosemid,
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• mp: 220 °C (dec.) (lit.)
• solubility: acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow
• originator: Sanofi Aventis
• storage temp.: room temp
• SMILES string: NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
• InChI: 1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
• InChI key: ZZUFCTLCJUWOSV-UHFFFAOYSA-N
• Gene Information: human ... ALB(213), CYP1A2(1544), SLC12A1(6557)

Beschreibung

General description

Furosemide is a an ototoxic high-ceiling diuretic.

Application

Furosemide has been used:

• to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
• to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
• as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Biochem/physiol Actions

Hemmt den Ionen-Co-Transport in der Niere

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.

Furosemide can block the Na⁺/K⁺/2Cl^- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H360FD
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges