D7321

Diosmetin

• Synonym(e): 3′,5,7-Trihydroxy-4′-methoxy-flavon, 4′-Methyl-luteolin, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-chromen-4-on, Luteolin-4′-methylether
• Empirische Formel (Hill-System): C₁₆H₁₂O₆
• CAS-Nummer: 520-34-3
• Molekulargewicht: 300.26
• Beilstein: 294492
• EG-Nummer: 208-291-8
• MDL-Nummer: MFCD00017425
• UNSPSC-Code: 12352205
• PubChem Substanz-ID: 329798848
• NACRES: NA.25

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: light yellow to yellow
• Löslichkeit: DMSO: 1 mg/mL, clear, faintly yellow to greenish-yellow
• Anwendung(en): metabolomics; vitamins, nutraceuticals, and natural products
• Lagertemp.: 2-8°C
• SMILES String: COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
• InChIKey: MBNGWHIJMBWFHU-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Diosmetin is a methylated aglycone flavone of diosmin. It is present abundantly in citrus fruits, Olea europaea L. (olive tree) leaves, and in the legume of Acacia farnesiana tree.

Anwendung

Diosmetin has been used to test its protective effects on chronic stress memory and cognitive impairment in mice model.

Biochem./physiol. Wirkung

Diosmetin exhibits anti-inflammatory, anti-cancer, antimicrobial, phytoestrogenic, and neuroprotective properties. It displays cytoprotective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and activating nuclear factor erythroid 2–related factor 2 (Nrf2).

Flavonoid aus Citrus limon. Antioxidans. Hemmt Aktivierung von Karzinogenen durch die Hemmung des CYP1A1-Enzyms.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable