D2390

Dacarbazin

antineoplastic purine analog

• Synonym(e): 5-(3,3-Dimethyl-1-triazenyl)-imidazol-4-carboxamid, DTIC
• Empirische Formel (Hill-System): C₆H₁₀N₆O
• CAS-Nummer: 4342-03-4
• Molekulargewicht: 182.18
• NACRES: NA.85
• PubChem Substance ID: 24893683
• UNSPSC Code: 51102829
• EC Number: 224-396-1
• MDL number: MFCD00057167

Eigenschaften

• Quality Segment: 100
• form: powder or crystals
• solubility: 1 M HCl: 50 mg/mL
• antibiotic activity spectrum: neoplastics
• mode of action: DNA synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: CN(C)\N=N\c1[nH]cnc1C(N)=O
• InChI: 1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
• InChI key: FDKXTQMXEQVLRF-ZHACJKMWSA-N

Beschreibung

Application

Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.

Biochem/physiol Actions

Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis.[1] It is known to induce hepatotoxicity in mice.[2] Dacarbazine is not cell cycle-phase specific.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302 + H312 + H332,H315,H319,H335,H340,H350
• pcodes: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges