C8034

Anti-Clathrin antibody produced in goat

whole antiserum

• Synonym(e): Anti-CHC, Anti-CHC17, Anti-CLH-17, Anti-CLTCL2, Anti-Hc, Anti-MRD56
• UNSPSC Code: 12352203
• MDL number: MFCD00162235
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IF
• Citations: 7

Eigenschaften

• biological source: goat
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: whole antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• contains: 15 mM sodium azide
• species reactivity: human
• technique(s): indirect immunofluorescence: 1:20 using human foreskin fibroblasts
• UniProt accession no.: Q00610
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CLTC(1213)

Beschreibung

General description

Clathrin consists of three heavy chains, along with three light chains. The weight of heavy chains varies depending on the source of clathrin. It forms a three-legged structure, termed triskelion with three clathrin heavy chains (molecular weight 180,000 daltons per chain) and three non-covalently bound light chains having molecular weights of 30,000-40,000 daltons per chain. Although the term clathrin was originally used to designate the heavy chain component of triskelions, clathrin is now used to refer to the entire triskelion protein molecule.

Immunogen

clathrin from bovine brain coated vesicles

Application

Anti-Clathrin antibody was used:

• for incubating trophozites (2.105) in a study to determine the role of clathrin in endocytic process of fluid-phase pathway.
• in indirect immunofluorescence staining.
• for immunocytohistochemistry study of human platelets to study the colocalization of adhesive proteins with clathrin in human blood platelets.

Biochem/physiol Actions

Clathrin is the main constituent of the polygonal network that forms the layer of coated vesicles and coated pits. It is widely assumed that coated vesicles mediate the selective transfer of molecules and membrane components between specific membranous organelles within cells. It is a type of protein which plays an important function within the cell, including various types of intracellular transport processes.

The product specifically labels the heavy chain band of clathrin by immunoblotting.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable