C4542

Cyclobenzaprin -hydrochlorid

• Synonym(e): 5-(3-Dimethylaminopropyliden)-dibenzo[a,e]cycloheptatrien -hydrochlorid
• Empirische Formel (Hill-System): C₂₀H₂₁N · HCl
• CAS-Nummer: 6202-23-9
• Molekulargewicht: 311.85
• NACRES: NA.77
• PubChem Substance ID: 24278315
• UNSPSC Code: 12352200
• EC Number: 228-264-4
• MDL number: MFCD00079039
• Form: powder

Eigenschaften

• form: powder
• Quality Segment: 200
• originator: Johnson & Johnson
• SMILES string: Cl.CN(C)CC\C=C1\c2ccccc2C=Cc3ccccc13
• InChI: 1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H
• InChI key: VXEAYBOGHINOKW-UHFFFAOYSA-N
• Gene Information: human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

Beschreibung

General description

Cyclobenzaprine is a tricyclic agent, which has anti-depressant and anti-cholinergic properties. It lowers the tonic somatic motor activity of motor neuron systems. Cyclobenzaprine prevents the uptake of noradrenaline. It is used to treat neck, back and myofascial pain. Cyclobenzaprine functions as a nerve impulse inhibitor.

Application

Cyclobenzaprine hydrochloride has been used to study its effect on the muscles of dystrophin-deficient mdx5Cv mice.[1]

Cyclobenzaprine hydrochloride has been used to study its effects on the muscles of dystrophin-deficient mdx5Cv mice.[1]

Biochem/physiol Actions

Relaxans der Skelett-Muskulatur; reduziert Muskelkrämpfe durch Depression von Neuronen des Hirnstamms; 5-HT₂-Serotonin-Rezeptor-Antagonist.

Skelett Muskelrelaxans; 5-HT₂ Serotonin-Rezeptor-Antagonist.

Cyclobenzaprine hydrochloride is a type of tricyclic skeletal drug, which is commonly used as a muscle relaxant. It is very effective in treating intractable pain of cervical and lumbar origin caused by skeletal muscle spasm. cyclobenzaprine hydrochloride inhibit tonic α-mononeuronal excitation mediated by descending serotonergic systems by interacting with serotonin receptors at the spinal cord level.[2]

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H312 + H332
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves