C2247

CPPHA

≥98% (HPLC)

• Synonym(e): N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide, N-[4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
• Empirische Formel (Hill-System): C₂₂H₁₅ClN₂O₄
• CAS-Nummer: 693288-97-0
• Molekulargewicht: 406.82
• MDL-Nummer: MFCD12912405
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 329774983
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated
• Löslichkeit: DMSO: >20 mg/mL
• Ersteller: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Lagertemp.: −20°C
• SMILES String: Oc1ccccc1C(=O)Nc2ccc(Cl)cc2CN3C(=O)c4ccccc4C3=O
• InChI: 1S/C22H15ClN2O4/c23-14-9-10-18(24-20(27)17-7-3-4-8-19(17)26)13(11-14)12-25-21(28)15-5-1-2-6-16(15)22(25)29/h1-11,26H,12H2,(H,24,27)
• InChIKey: UFOUABRZSDGGAZ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

CPPHA is a positive allosteric modulator of mGluR5 receptor.

CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.

Leistungsmerkmale und Vorteile

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This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS09
• Signalwort: Warning
• H-Sätze: H410
• P-Sätze: P273 - P501
• Gefahreneinstufungen: Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable