C1230

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

≥90% (TLC), powder

• Synonym(e): Z-IETD-FMK
• Empirische Formel (Hill-System): C₃₀H₄₃FN₄O₁₁
• CAS-Nummer: 220760-26-9
• Molekulargewicht: 654.68
• NACRES: NA.77
• PubChem Substance ID: 329774744
• UNSPSC Code: 12352209
• MDL number: MFCD01861686
• Assay: ≥90% (TLC)
• Form: powder
• Quality level: 200

Eigenschaften

• InChI: 1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
• SMILES string: CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
• InChI key: CTXDBLYOEUERAT-VUVYEONESA-N
• biological source: synthetic (organic)
• assay: ≥90% (TLC)
• form: powder
• solubility: methanol: 10 mg/mL, DMSO: 20 mM, clear, colorless to light yellow
• shipped in: dry ice
• storage temp.: −20°C
• Quality Level: 200

Beschreibung

Application

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:

• to study the activity of caspase-8 in porcine kidney cells[1]
• to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells[2]
• to study its effects on retinal ganglion and astroglia in rat eyes[3]

Biochem/physiol Actions

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.[4]

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)