BMS-777607

Name: BMS-777607
Brand: SIGMA

≥98% (HPLC)

Synonym(e):

BMS-817378, N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₅H₁₉ClF₂N₄O₄

CAS-Nummer:

1025720-94-8

Molekulargewicht:

512.89

NACRES:

NA.77

PubChem Substance ID:

329774362

UNSPSC Code:

12352200

MDL number:

MFCD16495773

Technischer Dienst

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Unterstützung erhalten

Eigenschaften

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

room temp

SMILES string

ClC1=C(N)N=CC=C1OC2=CC=C(NC(C3=C(OCC)C=CN(C4=CC=C(F)C=C4)C3=O)=O)C=C2F

InChI

1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)

InChI key

VNBRGSXVFBYQNN-UHFFFAOYSA-N

Gene Information

human ... MET(4233)

Beschreibung

Biochem/physiol Actions

BMS-777607 is an ATP-competitive inhibitor of the Met kinase superfamily with IC₅₀values of 1.8, 3.9, 4.3, and 1.1 nM, respectively, for Ron, Met, Tyro-3, and AxI kinases. BMS-777607 has been studied in a variety of cancer models and has shown anti-cancer activity, causing increased apoptosis, and decreased proliferation and migration, although it has also been shown to induce polyploidy, which may lead to chemoresistance.

BMS-777607 is an ATP-competitive inhibitor of the Met kinase superfamily.

RON kinase inhibitor (RONi, BMS-777607) decreases recepteur d′origine nantais (RON) signaling. This Met kinase inhibitor represses prostate cancer metastatic phenotype in vitro, induced by hepatocyte growth factor.