B3306

Bisindolylmaleimide IV

Name: Bisindolylmaleimide IV
Brand: SIGMA
Price: 89.3 EUR

≥98% (TLC), solid

Synonym(e):

Ro 31-6233

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₀H₁₃N₃O₂

CAS-Nummer:

119139-23-0

Molekulargewicht:

327.34

NACRES:

NA.77

PubChem Substance ID:

24891709

UNSPSC Code:

12352111

MDL number:

MFCD00236432

Assay:

≥98% (TLC)

Form:

solid

Quality level:

200

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Unterstützung erhalten

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

solid

color

dark red

solubility

DMSO: soluble, methanol: soluble

storage temp.

−20°C

SMILES string

O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c4c[nH]c5ccccc45

InChI

1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

InChI key

DQYBRTASHMYDJG-UHFFFAOYSA-N

Gene Information

human ... CDK2(1017), EGFR(1956)
rat ... Prkca(24680)

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Dieser Artikel	B4056	B3931	B3681
Sigma-Aldrich B3306 Bisindolylmaleimide IV	Sigma-Aldrich B4056 Bisindolylmaleimide XI hydrochloride	Sigma-Aldrich B3931 Bisindolylmaleimide X hydrochloride	Sigma-Aldrich B3681 Bisindolylmaleimide VII
form solid	form solid	form solid	form solid
assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥90%	assay 96% (TLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility DMSO: soluble, methanol: soluble	solubility DMSO: soluble	solubility DMSO: soluble	solubility DMSO: soluble
color dark red	color -	color -	color -

Biochem/physiol Actions

Bisindolylmaleimides (BIM) comprises a group of 11 compounds from BIM-I to BIM-XI.[1] BIMs act as an inhibitor of protein kinase C (PKC).[1] They are derived from staurosporine.[2] BIM IX due to its proapoptotic functionality could be useful in targeting tumor proliferation.[3]

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells.

Sibasish Dolai et al.

Proteomics, 11(13), 2683-2692 (2011-06-02)

Basal-like breast cancers are commonly negative for expression of estrogen and progesterone receptors and HER-2 (triple-negative breast cancer), which makes this subtype of breast cancers more aggressive and less responsive to standard treatment. We have applied a small-scale chemical proteomics

Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220.

Abdullah Mayati et al.

PloS one, 10(12), e0144667-e0144667 (2015-12-15)

Ro 31-8220 is a potent protein kinase C (PKC) inhibitor belonging to the chemical class of bisindolylmaleimides (BIMs). Various PKC-independent effects of Ro 31-8220 have however been demonstrated, including inhibition of the ATP-binding cassette drug transporter breast cancer resistance protein.

Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.

Hui He et al.

The Prostate, 70(10), 1119-1126 (2010-03-25)

We have reported that human prostate cancer ARCaP(E) cells undertake epithelial to mesenchymal transition (EMT) when stimulated by certain soluble factors, and that EMT is regulated by surface receptor-elicited signaling pathways through protein phosphorylation. It is known that phorbol ester

Role of P2X7 receptor-mediated IL-18/IL-18R signaling in morphine tolerance: multiple glial-neuronal dialogues in the rat spinal cord.

Meng-Ling Chen et al.

The journal of pain : official journal of the American Pain Society, 13(10), 945-958 (2012-09-13)

The glial function in morphine tolerance has been explored, but its mechanisms remain unclear. Our previous study has showed that microglia-expressed P2X7 receptors (P2X7R) contribute to the induction of tolerance to morphine analgesia in rats. This study further explored the

A single amino acid residue controls Ca2+ signaling by an octopamine receptor from Drosophila melanogaster.

Max Hoff et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(7), 2484-2491 (2011-04-12)

Rhythmic activity of cells and cellular networks plays an important role in physiology. In the nervous system oscillations of electrical activity and/or second messenger concentrations are important to synchronize neuronal activity. At the molecular level, rhythmic activity can be initiated

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Global Trade Item Number

SKU	GTIN
B3306-1MG	04061833427651
B3306-5MG	04061833427668

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