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A9730

Adefovir dipivoxil

Synonym(e):

9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine

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Über diesen Artikel

Empirische Formel (Hill-System):
C20H32N5O8P
CAS-Nummer:
142340-99-6
Molekulargewicht:
501.47
NACRES:
NA.76
PubChem Substance ID:
329771057
UNSPSC Code:
51102829
MDL number:
MFCD00869897

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Unterstützung erhalten

biological source

synthetic

Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

ethanol: 50 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CC(C)(C)C(=O)OCOP(=O)(COCCn1cnc2c(N)ncnc12)OCOC(=O)C(C)(C)C

InChI

1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)

InChI key

WOZSCQDILHKSGG-UHFFFAOYSA-N

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Dieser Artikel
SML0240F7932SML1795
Adefovir dipivoxil

Sigma-Aldrich

A9730

Adefovir dipivoxil

Adefovir ≥98% (HPLC)

Sigma-Aldrich

SML0240

Adefovir

Famciclovir ≥98% (HPLC)

Sigma-Aldrich

F7932

Famciclovir

Tenofovir ≥98% (HPLC)

Sigma-Aldrich

SML1795

Tenofovir

antibiotic activity spectrum

viruses

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

mode of action

enzyme | inhibits

mode of action

-

mode of action

-

mode of action

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

solid

form

powder

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

solubility

ethanol: 50 mg/mL

solubility

0.1 M NaOH: ≥5 mg/mL

solubility

DMSO: ≥10 mg/mL

solubility

H2O: 2 mg/mL, clear (warmed)

Biochem/physiol Actions

Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog that works by blocking reverse transcriptase.[1] It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification.[2] Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1).[3] Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages .

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral

Lagerklasse

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCN1196
BCCL6998
BCCJ4542
BCCD7131
BCBV6452

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Die Dokumentenbibliothek aufrufen

Man-Fung Yuen et al.
Expert opinion on pharmacotherapy, 5(11), 2361-2367 (2004-10-27)
Adefovir dipivoxil, an acyclic nucleotide analogue, is effective for the treatment of chronic hepatitis B in both hepatitis B e antigen (HBeAg)-positive and -negative patients, with improvement in liver histology, hepatitis B virus (HBV) DNA levels, alanine aminotransferase levels, and
Patrick Marcellin et al.
The New England journal of medicine, 348(9), 808-816 (2003-02-28)
In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains. We randomly assigned 515 patients with chronic hepatitis B who were positive for hepatitis B e antigen (HBeAg) to receive 10
Myron J Tong et al.
Seminars in liver disease, 24 Suppl 1, 37-44 (2004-06-12)
Adefovir dipivoxil, a nucleotide analog of adenosine monophosphate, is an antiviral agent that suppresses hepatitis B virus (HBV) replication through inhibition of DNA polymerase and by chain termination. To determine the effectiveness of adefovir, three populations of patients with chronic
J Jones et al.
Health technology assessment (Winchester, England), 13(35), 1-172 (2009-07-18)
To update and extend a 2006 report on the clinical effectiveness and cost-effectiveness of adefovir dipivoxil (ADV) and pegylated interferon alpha (PEG-alpha) for the treatment of chronic hepatitis B (CHB). Thirteen bibliographic databases were searched including MEDLINE, EMBASE and the
Kazuya Maeda et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 59, 94-103 (2014-04-22)
Probe substrates for, and inhibitors of, specific transporters are desired to evaluate quantitatively the in vivo functions of transporters in humans. Based on published data, adefovir and benzylpenicillin were selected as organic anion transporter (OAT) 1- and OAT3-selective probe substrates
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Global Trade Item Number

SKUGTIN
A9730-100MG04061832989884
A9730-25MG04061832989891
A9730-50MG04061832989907

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