A8404

Amitriptylin -hydrochlorid

≥98% (TLC), powder

• Empirische Formel (Hill-System): C₂₀H₂₃N · HCl
• CAS-Nummer: 549-18-8
• Molekulargewicht: 313.86
• EG-Nummer: 208-964-6
• MDL-Nummer: MFCD00012537
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278073
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (TLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: H₂O: soluble; ethanol: soluble
• Ersteller: Bristol-Myers Squibb
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• InChIKey: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Angaben zum Gen: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , SLC6A2(6530) , SLC6A4(6532)

Beschreibung

Anwendung

Amitriptyline hydrochloride has been used:

• as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice
• as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood
• as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse

Biochem./physiol. Wirkung

Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia. It possesses antihistaminic, anticholinergic, and antiserotonimic properties. Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Leistungsmerkmale und Vorteile

Shelf-life of the powder is at least three years.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08,GHS09
• Signalwort: Danger
• H-Sätze: H301,H319,H361d,H410
• P-Sätze: P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges