A8404

Amitriptylin -hydrochlorid

≥98% (TLC), norepinephrine and serotonin transporter inhibitor, powder

• Empirische Formel (Hill-System): C₂₀H₂₃N · HCl
• CAS-Nummer: 549-18-8
• Molekulargewicht: 313.86
• NACRES: NA.77
• PubChem Substance ID: 24278073
• UNSPSC Code: 12352200
• EC Number: 208-964-6
• MDL number: MFCD00012537
• Assay: ≥98% (TLC)
• Form: powder

Eigenschaften

• Produktname: Amitriptylin -hydrochlorid, ≥98% (TLC), powder
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• color: white to off-white
• solubility: H₂O: soluble, ethanol: soluble
• originator: Bristol-Myers Squibb
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• InChI key: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), SLC6A2(6530), SLC6A4(6532)

Beschreibung

Application

Amitriptyline hydrochloride has been used:

• as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice[1]
• as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood[2]
• as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse[3]

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia.[4] It possesses antihistaminic, anticholinergic, and antiserotonimic properties. Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.[4]

Features and Benefits

Shelf-life of the powder is at least three years.

Sicherheitshinweise

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H301,H319,H361d,H410
• pcodes: P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges