A6605

AMN082

≥98% (HPLC), solid

• Synonym(e): N,N′-Dibenzhydrylethane-1,2-diamine dihydrochloride
• Empirische Formel (Hill-System): C₂₈H₂₈N₂ · 2HCl
• CAS-Nummer: 97075-46-2
• Molekulargewicht: 465.46
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891112
• MDL number: MFCD08702723

Eigenschaften

• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: ≥5 mg/mL
• storage temp.: −20°C
• SMILES string: Cl[H].Cl[H].C(CNC(c1ccccc1)c2ccccc2)NC(c3ccccc3)c4ccccc4
• InChI: 1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
• InChI key: YRQCDCNQANSUPB-UHFFFAOYSA-N

Beschreibung

Application

AMN082 is a selective allosteric mGluR 7 receptor agonist and has been used to study the role of this glutamate receptor type in the medial prefrontal cortex in mice. AMN082 inhibits forskolin-stimulated cAMP accumulation, and stimulates not only GTPγS binding but also the release of stress hormones.

Biochem/physiol Actions

AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 inhibits forskolin-stimulated cAMP accumulation (EC₅₀ = 64 nM) and stimulates GTPγS binding (EC₅₀ = 290 nM) similar to L-AP₄ and greater than L-glutamate. Thus, AMN082 is a "full agonist" and acts at an allosteric site in the transmembrane domain of mGluR7. AMN082 has no effects at other mGluR′s up to 10 μM and stimulates release of stress hormones (corticosterone and ACTH) and is orally active and brain penetrable.

AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 stimulates the release of stress hormones (corticosterone and ACTH), orally active and brain penetrable.

Sicherheitshinweise

• Lagerklasse: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves