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94956

Vinyl-cyclohexen-dioxid

purum, suitable for electron microscopy, mixture of isomers, ≥96.0% (GC)

Synonym(e):

1-Epoxyethyl-3,4-epoxycyclohexan, 3-Epoxyethyl-7-oxabicyclo[4.1.0]heptan

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€ 381,00

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€ 549,75

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Über diesen Artikel

Empirische Formel (Hill-System):
C8H12O2
CAS-Nummer:
106-87-6
Molekulargewicht:
140.18
UNSPSC Code:
12162002
NACRES:
NA.25
PubChem Substance ID:
57653591
EC Number:
203-437-7
Beilstein/REAXYS Number:
106071
MDL number:
MFCD00022354
Assay:
≥96.0% (GC)
Form:
liquid
Quality level:
100

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Quality Level

100

grade

purum

assay

≥96.0% (GC)

form

liquid

technique(s)

electron microscopy: suitable

refractive index

n20/D 1.477 (lit.), n20/D 1.479

bp

230-232 °C (lit.)

density

1.094 g/mL at 25 °C (lit.)

SMILES string

C1CC2OC2CC1C3CO3

InChI

1S/C8H12O2/c1-2-6-7(10-6)3-5(1)8-4-9-8/h5-8H,1-4H2

InChI key

OECTYKWYRCHAKR-UHFFFAOYSA-N

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1 of 4

Dieser Artikel
669911152544C102504
Vinylcyclohexene dioxide purum, suitable for electron microscopy, mixture of isomers, ≥96.0% (GC)

Sigma-Aldrich

94956

Vinylcyclohexene dioxide

3,4-Epoxy-1-cyclohexene ≥96.0%

Sigma-Aldrich

669911

3,4-Epoxy-1-cyclohexene

4-Vinyl-1-cyclohexene 1,2-epoxide, mixture of isomers 98%

152544

4-Vinyl-1-cyclohexene 1,2-epoxide, mixture of isomers

Cyclohexene oxide 98%

Sigma-Aldrich

C102504

Cyclohexene oxide

form

liquid

form

-

form

liquid

form

liquid

assay

≥96.0% (GC)

assay

≥96.0% (GC)

assay

98%

assay

98%

technique(s)

electron microscopy: suitable

technique(s)

-

technique(s)

-

technique(s)

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

grade

purum

grade

-

grade

-

grade

-

refractive index

n20/D 1.477 (lit.)

refractive index

-

refractive index

n20/D 1.469 (lit.)

refractive index

n20/D 1.452 (lit.)

Application

Vinylcyclohexene dioxide (VCD) may be used to study and understand its effect on ovarian follicles and effects on epithelial differentiation.

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signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1B

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

224.6 °F - closed cup

flash_point_c

107 °C - closed cup

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Zulassungslistungen

Zulassungslistungen werden hauptsächlich für chemische Produkte erstellt. Für nicht-chemische Produkte können hier nur begrenzte Angaben gemacht werden. Kein Eintrag bedeutet, dass keine der Komponenten gelistet ist. Es liegt in der Verantwortung des Benutzers, die sichere und legale Verwendung des Produkts zu gewährleisten.

106-87-6

CAS No.

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCP2522
BCCN3434
BCCM3213
BCCM5102
BCCJ4415

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Suche nach COA

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Aileen F Keating et al.
Toxicology and applied pharmacology, 247(2), 71-75 (2010-06-15)
The occupational chemical 4-vinylcyclohexene diepoxide (VCD) selectively destroys ovarian small pre-antral follicles in rats and mice via apoptosis. Detoxification of VCD can occur through glutathione conjugation, catalyzed by glutathione S-transferase (GST) enzymes. Further, GST class pi (GSTp) can negatively regulate
Laura A Laviolette et al.
Menopause (New York, N.Y.), 18(5), 549-557 (2011-01-12)
Ovarian cancer is often diagnosed in women after menopause when the levels of the serum gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are increased because of the depletion of growing follicles within the ovary. The ability of FSH and
Connie J Kappeler et al.
Systems biology in reproductive medicine, 58(1), 57-62 (2012-01-14)
The occupational chemical 4-vinylcyclohexene diepoxide (VCD) has been shown to cause selective destruction of ovarian small pre-antral (primordial and primary) follicles in rats and mice by accelerating the natural, apoptotic process of atresia. Chemicals that destroy primordial follicles are of
Connie J Mark-Kappeler et al.
Biology of reproduction, 85(4), 755-762 (2011-06-17)
In vitro exposure of Postnatal Day 4 (PND4) rat ovaries to the occupational chemical 4-vinylcyclohexene diepoxide (VCD) destroys specifically primordial and primary follicles via acceleration of atresia. Because oocyte-expressed c-kit (KIT) plays a critical role in follicle survival and activation
Carmen Terren et al.
Scientific reports, 9(1), 19668-19668 (2019-12-25)
Slow freezing (SF) is the reference method for ovarian tissue cryopreservation. Vitrification (VT) constitutes an alternative but controversial method. This study compares SF and VT (open [VTo] and closed [VTc] systems) in terms of freezing damage and fertility restoration ability.
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Global Trade Item Number

SKUGTIN
94956-250ML04061833297216
94956-100ML04061838177520

Questions

1–7 of 7 Questions  

  1. マウスの閉経モデルを作成するのに使いたいのですが、本来使おうとしていた試薬は販売中止でこちらの代替品を勧められました。こちらで閉経モデルを作成するにあたっての用法容量などの注意点はありますか？

    1 answer

    1. This product has not been tested for in vivo or in vitro use. However, it has been used successfully by other researchers to induce menopause in mouse models. Please see the links below to review example publications:

      Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome
      https://pmc.ncbi.nlm.nih.gov/articles/PMC2739794/

      Accelerated Ovarian Failure: a novel, chemically-induced animal model of menopause
      https://pmc.ncbi.nlm.nih.gov/articles/PMC3078694/

      Helpful?

  2. For the purpose of our study, we will be injecting 4-VCD dissolved in sesame oil for 20 consecutive days. Can the mixture be stored at four degree for a few days to avoid the hustle of freezing and thawing?

    1 answer

    1. Unfortunately, there is no data available on the stability of this mixture when stored at 4 °C.

      Helpful?

  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  4. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  5. How should VCD be stored, for short term and long term?

    1 answer

    1. This product may be stored at room temperature for both, short and long term periods.

      Helpful?

  6. What is the concentration of VCD #94956 ( mg / ml)?

    1 answer

    1. This product is supplied as a neat or pure liquid with a density of 1.094 g/mL and a molecular weight of 140.18 g/mol. The minimum purity is 96%, thus the molarity will vary slightly from lot to lot. The molarity can range from 7.5 M (96%) to 7.8 M (100%). The lot specific purity is reported on the Certificate of Analysis. Please see the link below to review a sample Certificate: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/94956-BULKBCCJ4415.pdf

      Helpful?

  7. ¿En qué está disuelto este producto (94956): aceite de sesamo, Alcohol, DMSO? . Tengo que usarlo más diluido para inyectar en ratones. Gracias

    1 answer

    1. Product 94956 is a neat liquid of Vinylcyclohexene dioxide (VCD) at room temperature. According to the following scientific article, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703138/, VCD was either prepared for intramuscular injection with cottonseed oil, or prepared with sesame oil for intraperitoneal injection.

      Helpful?

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