74675

Novobiocin Natriumsalz

≥93% (HPLC)

• Synonym(e): Albamycin, Cathomycin, Novobiocin, Novobiocin, Monosodium Salt
• Empirische Formel (Hill-System): C₃₁H₃₅N₂NaO₁₁
• CAS-Nummer: 1476-53-5
• Molekulargewicht: 634.61
• Beilstein: 3892910
• EG-Nummer: 216-023-6
• UNSPSC-Code: 51101500
• NACRES: NA.85

Eigenschaften

• Assay: ≥93% (HPLC)
• Form: powder
• Optische Aktivität: [α]20/D −48±3°, c = 1% in ethanol
• Farbe: white to faint beige
• Löslichkeit: H₂O: soluble
• Wirkungsspektrum von Antibiotika: Gram-positive bacteria
• Wirkungsweise: DNA synthesis | interferes; enzyme | inhibits
• Lagertemp.: 2-8°C
• SMILES String: [Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C
• InChI: 1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
• InChIKey: AXOUUAINTJNFRS-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: coumarin-glycoside

Anwendung

Novobiocin is used to study heat shock protein inhibition and to produce positively supercoiled plasmid DNA. It is an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. It also is an inhibitor of retrovirus RNA-dependent DNA-polymerase.

Für die Produktion von positiv superspiralisierter Plasmid-DNA. Inhibitor von bakterieller DNA-Gyrase und eukaryotischer DNA-Topoisomerase. Inhibitor von RNA-abhängiger DNA-Polymerase aus Retroviren.

Biochem./physiol. Wirkung

Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitors of the ATPase reaction catalysed by GyrB . It is also a Hsp90 inhibitor . Antimicrobial spectrum: Gram-positive bacterial.

Wirkungsweise: Hemmt die DNA-Synthese durch Hemmen des Enzyms Topoisomerase II.
Antimikrobielles Spektrum: Grampositiv, bakteriell.

Verpackung

1g, 5g

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Store under inert gas. Keep in a dry place.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H317,H319
• P-Sätze: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves