Fortfahren mit
427M-9
p27Kip1 (SX53G8) Mouse Monoclonal Antibody
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Über diesen Artikel
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SX53G8, monoclonal
Application:
IHC (p)
Citations:
11
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Technischer Dienst
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Unterstützung erhaltenbiological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
SX53G8, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (427M-94), vial of 0.5 mL concentrate (427M-95), bottle of 1.0 mL predilute (427M-97), vial of 1.0 mL concentrate (427M-96), bottle of 7.0 mL predilute (427M-98)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype
IgG1κ
control
tonsil
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Gene Information
rat ... Cdkn1B(83571)
General description
p27 is a cyclin-dependent kinase inhibitor which regulates progression from G1 to S phase by binding and inhibiting cyclin-dependent kinases. Low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, small breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, lymph node metastases in Papillary carcinoma of the Thyroid, and more aggressive phenotype in carcinoma of the cervix.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
p27Kip1 Positive Control Slides, Product No. 427S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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V Esposito et al.
Cancer research, 57(16), 3381-3385 (1997-08-15)
Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibitor genes, has never been found mutated in human tumors. We investigated p27 protein expression in a series of 108 non-small
P Tan et al.
Cancer research, 57(7), 1259-1263 (1997-04-01)
Breast carcinomas < or = 1 cm in size (T1a,b) are being detected more frequently as a result of screening. Because traditional prognostic parameters are either lacking (tumor size) or rare (nodal metastases), a marker(s) is needed to identify the
Maria J Ribal et al.
Anticancer research, 23(6D), 5101-5106 (2004-02-26)
To assess the prognostic value of p27 protein expression in clinically localised prostate cancer with respect to biochemical recurrence after radical prostatectomy. Fifty-two patients (median age 63 years) with prostate cancer were treated by radical prostatectomy in an 18-month period.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 427M-96 | 0841683142317 |
| 427M-97 | 0841683142324 |
| 427M-95 | 0841683142300 |
| 427M-98 | 0841683142331 |
| 427M-94 | 0841683142294 |