10791

Antipain

>50000 U/mg

• Synonym(e): [(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal
• Empirische Formel (Hill-System): C₂₇H₄₄N₁₀O₆
• CAS-Nummer: 37691-11-5
• Molekulargewicht: 604.70
• UNSPSC Code: 12352202
• NACRES: NA.77
• PubChem Substance ID: 57646816
• EC Number: 253-631-0
• Beilstein/REAXYS Number: 6837629
• MDL number: MFCD00135959

Eigenschaften

• Quality Segment: 100
• specific activity: >50000 U/mg
• input: general use sample(s)
• mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: [H]C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C(C)C
• InChI: 1S/C27H44N10O6/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)/t18?,19-,20-,21-/m0/s1
• InChI key: SDNYTAYICBFYFH-KTYMLHDXSA-N

Beschreibung

General description

Chemical structure: peptide

Biochem/physiol Actions

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

1 U entspricht der Inhibitormenge, welche die Trypsinaktivität um 1 BAEE-U reduziert. (1 BAEE-U ist die Enzymmenge, die bei 253 nm eine Extinktionszunahme von 0.001 pro Minute bei pH 7.6 und 25°C bewirkt; BAEE, Fluka^®-Nr. 12880, als Substrat)

Protease inhibitor[1]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)