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Merck

B5775

Supelco

Bendroflumethiazid

analytical standard

Synonym(e):

3-Benzyl-6-trifluormethyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-1,1-dioxid

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About This Item

Empirische Formel (Hill-System):
C15H14F3N3O4S2
CAS-Nummer:
Molekulargewicht:
421.41
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Format

neat

SMILES String

NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F

InChI

1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)

InChIKey

HDWIHXWEUNVBIY-UHFFFAOYSA-N

Angaben zum Gen

human ... SLC12A3(6559)

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Allgemeine Beschreibung

Bendroflumethiazide belongs to the class of thiazide diuretics, widely used in enhancing diuresis. It is also used as an effective antihypertensive agent and in the treatment of edema caused by cardiac/renal failure and myocardial infarction. Its mode of action involves increasing the urine flow and the net renal excretion of both sodium and water.

Anwendung

Bendroflumethiazide may be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Anwendung

Produkt-Nr.
Beschreibung
Preisangaben

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Analysenzertifikate (COA)

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David S Wald et al.
Journal of evaluation in clinical practice, 18(3), 612-615 (2011-02-01)
A combination of medications that simultaneously reduce several cardiovascular risk factors in people above a specified age, without selection based on risk factor measurement, has been proposed as a simple strategy for reducing the risk of cardiovascular disease and shown
Hari K Parthasarathy et al.
Journal of hypertension, 28(1), 170-177 (2009-12-17)
We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750
Neil R Poulter et al.
Journal of the American College of Cardiology, 54(13), 1154-1161 (2009-09-19)
The aim of this study was to evaluate the effect of baseline heart rate on the efficacy of atenolol-based compared with amlodipine-based therapy in patients with hypertension uncomplicated by coronary heart disease in the ASCOT-BPLA (Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure
Quaisar Ali et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 35(6), 654-660 (2012-02-03)
Previously, we demonstrated that angiotensin II type 2 (AT(2)) receptors have a role in natriuresis in obese Zucker rats (OZR). In the present study, we investigated the role of a novel, non-peptide agonist, C21, in natriuresis via AT(2) receptor activation
The
Current Cardiovascular Drugs, 9(4), 1069-1076 (2005)

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