22632

Chinin -hydrochlorid Dihydrat

tested according to Ph. Eur.

• Synonym(e): Chinini hydrochloridum, (8α, 9R)-6′-Methoxycinchonan-9-ol -monohydrochlorid Dihydrat
• Empirische Formel (Hill-System): C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• CAS-Nummer: 6119-47-7
• Molekulargewicht: 396.91
• UNSPSC Code: 12352210
• NACRES: NA.25
• PubChem Substance ID: 329752329
• EC Number: 205-001-1
• Beilstein/REAXYS Number: 6112655
• MDL number: MFCD00151248
• Form: solid

Eigenschaften

• agency: tested according to Ph. Eur.
• Quality Segment: 100
• form: solid
• solubility: water: soluble 0.25 mg in 5 ml
• application(s): research use (small molecule)
• SMILES string: O.O.Cl.COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
• InChI: 1S/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13-,14-,19-,20+;;;/m0.../s1
• InChI key: MPQKYZPYCSTMEI-FLZPLBAKSA-N

Beschreibung

Application

Quinine hydrochloride dehydrate has been used for fluorescent in situ detection of quinine in cinchona bark using UV resonance raman spectroscopy.[1] It has also been used as a actinometric system to measure the light-induced changes in ruthenium anticancer agent, NAMI-A.[2]

Biochem/physiol Actions

Quinine is a very effective anti-malarial treatment but is considered toxic for routine treatment due to the development of drug resistance in the malarial parasites. It acts as blood schizonticide.[3]Quinine reportedly blocks the membrane conductance of potassium in enteric neurons.[4]

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H317,H334
• pcodes: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves