21186

Calcium-Ionophor III

Selectophore^™, function tested

• Synonym(e): Kalzium-Ionophor A23187, Antibiotic A 23187, Calcimycin
• Empirische Formel (Hill-System): C₂₉H₃₇N₃O₆
• CAS-Nummer: 52665-69-7
• Molekulargewicht: 523.62
• UNSPSC Code: 26111700
• NACRES: NB.61
• PubChem Substance ID: 329752113
• EC Number: 258-084-1
• Beilstein/REAXYS Number: 1096801
• MDL number: MFCD00151202

Eigenschaften

• description: for ion-selective electrodes
• Quality Segment: 200
• product line: Selectophore^™
• form: solid
• quality: function tested
• antibiotic activity spectrum: Gram-positive bacteria, fungi
• mode of action: cell membrane | interferes
• storage temp.: 2-8°C
• SMILES string: [H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
• InChI: 1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
• InChI key: HIYAVKIYRIFSCZ-CYEMHPAKSA-N

Beschreibung

General description

Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca²⁺ ions across membranes along a concentration gradient.

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Application

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca²⁺ dependent K⁺ channels as the K⁺ efflux.

Das Ionophor ist hochselektiv für Ca²⁺. Verstärkt die Response auf NMDA- aber nicht auf Quisqualat-Rezeptoren. In Zellkultur stimuliert es die Stickstoffmonoxidbildung durch calmodulinabhängige konstitutive NO-Synthase.

Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Preparation of an optical chemical sensor for Ca²⁺ and Mg²⁺

Legal Information

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves