14385

Biochanin A

≥97.0% (TLC)

• Synonym(e): 4′-Methylgenistein, 5,7-Dihydroxy-4′-methoxy-isoflavon, Genistein 4′-Methyl- Ether, Olmelin
• Empirische Formel (Hill-System): C₁₆H₁₂O₅
• CAS-Nummer: 491-80-5
• Molekulargewicht: 284.26
• EC Number: 207-744-7
• UNSPSC Code: 12352200
• MDL number: MFCD00006839
• Beilstein/REAXYS Number: 278107

Eigenschaften

• assay: ≥97.0% (TLC)
• mp: 210-213 °C (lit.), 212-218 °C
• solubility: acetone: 10 mg/mL, clear, brown
• SMILES string: COc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
• InChI: 1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3
• InChI key: WUADCCWRTIWANL-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Biochanin A is an isoflavone phytoestrogen found in red clover (Trifolium pratense) that is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects.

Biochanin A is an isoflavone phytoestrogen found in red clover (Trifolium pratense) that is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.