06734

Tamoxifen

certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

• Synonym(e): (Z)-1-(p-Dimethylaminethoxyphenyl)-1,2-diphenyl-1-buten, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamin
• Lineare Formel: C₆H₅C(C₂H₅)=C(C₆H₅)C₆H₄OCH₂CH₂N(CH₃)₂
• CAS-Nummer: 10540-29-1
• Molekulargewicht: 371.51
• NACRES: NA.24
• PubChem Substance ID: 329748268
• UNSPSC Code: 41116107
• EC Number: 234-118-0
• MDL number: MFCD00010454

Eigenschaften

• Quality Segment: 300
• product line: TraceCERT^®
• grade: certified reference material, TraceCERT^®
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
• storage condition: under inert gas (Argon)
• technique(s): gas chromatography (GC): suitable
• mp: 97-98 °C (lit.)
• format: neat
• storage temp.: 2-8°C
• SMILES string: CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCN(C)C)cc3
• InChI: 1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
• InChI key: NKANXQFJJICGDU-QPLCGJKRSA-N
• Gene Information: human ... ESR1(2099)

Beschreibung

General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com

Biochem/physiol Actions

Proteinkinase C-Inhibitor. Induziert Apoptose in menschlichen malignen Gliomzelllinien. Tamoxifen und sein Metabolit 4-Hydroxytamoxifen sind selektive Östrogenrezeptormodulatoren (SERM), die als Östrogen-Antagonisten in Brustdrüsen wirken. Hemmt die Estradiol-stimulierte VEGF-Produktion in Brustkrebszellen.

Östrogen-Antagonist in der Brustdrüse. Hemmt die Östradiol-stimulierte VEGF-Produktion in Brustkrebszellen. Proteinkinase C-Inhibitor.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• pictograms: GHS08,GHS09
• signalword: Danger
• hcodes: H350,H360,H410
• pcodes: P201 - P273 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable