MAB379
Anti-Glutamate Receptor 5, 6, 7 Antibody, clone 4F5
ascites fluid, clone 4F5, Chemicon®
Synonym(e):
GluR5/6/7
Größe auswählen
| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 100 μL | Warenkorb auf Verfügbarkeit prüfen | € 545,00 |
Über diesen Artikel
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
4F5, monoclonal
species reactivity
rat, human, monkey
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, radioimmunoassay: suitable
isotype
IgM
NCBI accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... GRIK1(2897)
Immunogen
Application
ELISA
RIA
Optimal working dilutions must be determined by end user.
Neuroscience
Neurotransmitters & Receptors
Biochem/physiol Actions
Physical form
Preparation Note
Legal Information
Disclaimer
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| biological source mouse | biological source mouse | biological source mouse | biological source rabbit |
| antibody form ascites fluid | antibody form purified immunoglobulin | antibody form purified immunoglobulin | antibody form affinity purified immunoglobulin |
| species reactivity rat, human, monkey | species reactivity monkey, human, rat | species reactivity rat, monkey, human, Xenopus | species reactivity rat |
| clone 4F5, monoclonal | clone 3A11, monoclonal | clone 54.1, monoclonal | clone polyclonal |
| Gene Information human ... GRIK1(2897) | Gene Information human ... GRIA2(2891) | Gene Information frog ... Grin1(780048) | Gene Information human ... GRIA1(2890) |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate - |
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Lagerklasse
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
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Verwandter Inhalt
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MAB379 | 04053252464515 |